Genome editing is a set of techniques for introducing targeted changes in genomes.It may be achieved by enzymes collectively called site-directed nucleases (SDN).Site-specificity of SDNs is provided either by the DNA binding domain of the protein molecule itself or by RNA molecule(s) that direct SDN to a specific site in the genome.In contrast to t
The purpose of this report is to provide cost of capital formulae for assessing the effects of taxation on the incentive to invest in oil and gas industries in Canada.The analysis is based on the assumption that businesses invest in capital until the after-tax rate of return on capital is equal to the tax-adjusted cost of capital.The cost of capita
Abstract In the present study, we describe two novel cases of SCA5 with early onset.The first one, carrying a novel heterozygous de novo missense mutation in SPTBN2 gene, showed a striking very severe cerebellar atrophy and reduction Fittings of volume of the pons at a very young age (16 months).The latter, carrying the first de novo intragenic del
Thymidine kinase 1 (TK1) phosphorylates thymidine nucleosides to generate thymidine monophosphate.This reaction belongs to the pyrimidine salvage route that is phylogenetically conserved.In the model plant Arabidopsis thaliana, TK activity contributes to maintain nuclear and organellar genome integrity by providing deoxythymidine-triphosphate (dTTP